In vivo and in vitro effects of cadmium on selected enzymes in different organs of the fish Barbus conchonius ham. (Rosy Barb) |
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| Institution: | 1. Department of Anatomy, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pa. 19107, U.S.A. (Telephone: (215) 955-7820; Fax: (215) 923-3808);2. Department of Zoology, Faculty of Science, Kumaun University, Naini Tal 263 002, India;1. Division for Quantitative Sustainability Assessment, Department of Management Engineering, Technical University of Denmark, Produktionstorvet, Building 426, DK-2800 Kgs. Lyngby, Denmark;2. Department of Environmental Science, Institute for Wetland and Water Research, Faculty of Science, Radboud University Nijmegen, P.O. Box 9010, NL-6500 GL Nijmegen, The Netherlands;1. Department of Plant Protection/Biological Control Studies and Research Center, Faculty of Agriculture, University of Damascus, Damascus, Syria;2. INRA, Unité PSH, Equipe Ecologie de la Production Intégrée, Domaine St. Paul, Site Agroparc, 84914 Avignon Cedex 9, France;1. Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, Sichuan, China;2. Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, Sichuan, China;3. Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Sichuan Agricultural University, Chengdu 611130, Sichuan, China |
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| Abstract: | 1. Enzyme modulation by cadmium in selected organs of the fish, Barbus conchonius (rosy barb), was investigated in vivo (48 hr exposure to 12.6 mg/1 cadmium chloride) and in vitro (10?6M cadmium chloride).2. The acetylcholinesterase (AchE) activity was depressed in the gills but stimulated in the skeletal muscles and brain in vivo. The hepatic, branchial, and renal acid phosphatase (AcP) activity decreased marginally in vivo but it was significantly increased in the gut and ovary. In vitro, except for the liver, the AcP activity was depressed in the selected organs. Collaterally, gut alkaline phosphatase (A1P) was significantly inhibited but a pronounced stimulation was noted in the kidneys and ovary in vivo. In vitro, the AIP activity was conspicuously elevated in the kidneys and gut, and moderately in the gills.3. Cadmium inhibited the glutamate-oxaloacetate and glutamate-pyruvate transaminases (GOT and OPT) in the liver, gills and kidneys in vivo. In vitro, the GOT and GPT activities were decreased in the liver, gills and kidneys. The lactic dehydrogenase (LDH) was significantly stimulated by Cd in the heart in vivo but in vitro the metal inhibited the enzyme in the gills.4. Enzymes in the liver, followed by those in the kidneys and gills seem to be most seriously affected by Cd poisoning in this fish. |
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