Time-dependent cadmium-neurotoxicity in rat brain synaptosomal plasma membranes |
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| Institution: | 1. Department of Occupational Health (Key Laboratory of Electromagnetic Radiation Protection, Ministry of Education), Army Medical University (Third Military Medical University), Chongqing 400038, China;2. Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing 400030, China;3. Department of Environmental Medicine, School of Public Health, and Department of Emergency Medicine, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China;4. Department of Breast Surgery, Central Hospital of Zhuzhou City, Central South University, Zhuzhou 412000, Hunan, China;5. Biomedical Analysis Center, Army Medical University (Third Military Medical University), Chongqing 400038, China;6. School of Medicine, Guangxi University, Nanning 530004, Guangxi, China;7. State key Laboratory Of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University), Chongqing 400038, China |
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| Abstract: | - 1.1. The modulation of lipid dynamics and lipid protein interactions were studied in rat brain synaptosomal plasma membranes (SPM) up to 24 hr after exposure to cadmium (Cd).
- 2.2. The activity of acetylcholinesterase and adenylate cyclase showed a considerable decrease after 6 hr of Cd exposure, followed by a progressive increase up to 24 hr.
- 3.3. SPM chemiluminescence showed a maximum decrease at 12 hr, demonstrating a considerable increase in lipid peroxidation.
- 4.4. SPM of Cd-exposed animals showed a statistical significant increase in fluorescence anisotropy parameter (r0/r) — 1]?1 at 18 and 24 hr compared to SPM of the control, indicating a decrease of membrane fluidity.
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