Evaluation of two new bifunctional chelates for radiolabeling a parathyroid-specific monoclonal antibody with In-111 |
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| Institution: | 1. The Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway, St Louis, MO 63110, U.S.A.;2. Department of Chemistry, Texas A&M University, College Station, TX 77840, U.S.A.;3. Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, U.S.A.;1. Department of Civil Engineering, Faculty of Engineering and Architecture, Bitlis Eren University, TR-13000, Bitlis, Türkiye;2. Çan Vocational School, Çanakkale Onsekiz Mart University, TR-17400, Çanakkale, Türkiye;3. Department of Civil Engineering, Faculty of Engineering Middle East Technical University, TR-06410, Ankara, Türkiye;4. Department of Civil Engineering, Faculty of Engineering, Konya Technical University, TR-42250, Konya, Türkiye;5. Institute of Structural Mechanics (ISM), Bauhaus-Universität Weimar, 99423 Weimar, Germany;6. Çanakkale Municipality, Çanakkale TR-17000 Çanakkale, Türkiye;7. Provincial Directorate of Environment, Urbanization, and Climate Change, TR-13000, Bitlis, Türkiye;8. Department of Civil Engineering, Faculty of Engineering and Architecture, Burdur Mehmet Akif University, TR-15030, Burdur, Türkiye;1. Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCSS, Largo A. Gemelli 8, 00168 Rome, Italy;2. Institute of Paediatrics, Paediatric Cardiology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy;3. Department of Imaging, Ospedale Pediatrico Bambino Gesù IRCCS, 00165 Rome, Italy;4. Department of Paediatric Cardiology and Cardiac Surgery, Ospedale Pediatrico Bambino Gesù IRCCS, 00165 Rome, Italy;5. Università Cattolica del Sacro Cuore, 00168 Rome, Italy;1. Department of Neurology and Neurophysiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany;2. Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland;3. Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany;4. Radiology, Balgrist University Hospital, University of Zurich, Zurich, Switzerland;5. Department of Neurosurgery, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany;6. Department of Neuroradiology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany;7. University Spine Center Zurich, Balgrist University Hospital, University of Zurich, Zurich, Switzerland |
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| Abstract: | BB5-G1, a monoclonal antibody specific for human parathyroid cell membrane antigen was conjugated with two new ligands, BrMe2HBED and BrφHBED and radiolabeled with 111In. We have compared the biodistribution of 111In-labeled BBS using the new ligands to conventionally labeled (125I-labeled and 111In-DTPA-labeled) BBS in a nude mouse model. Both 111In-BrMe2HBED-BB5 and 111In-BrφHBED-BB5 attained high parathyroid-to-blood and parathyroid-to-muscle ratios by 72–96 h. 111In-BrφHBED-BB5 showed lower %ID/g than 111In-BrMe2HBED-BB5 in the clearance organs, the liver and kidney; renal activity had cleared significantly by 120 h. This work suggests that 111In-BrφHBED-BB5 offers improved in vivo behavior and may be useful as a radiopharmaceutical for localizing parathyroid tissue. |
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