Role of serum albumin as a carrier of 99mTc-complex to tumor tissue |
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| Institution: | 1. Faculty of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China;2. School of Material Science and Engineering, Jiangsu University, Zhenjiang 212013, China;1. Department of Chemical Engineering, Aristotle University of Thessaloniki, University Campus, GR-54124 Thessaloniki, Greece;2. Chemical Process and Energy Resources Institute (CERTH/CPERI), P.O. Box 60361 Thermi, Thessaloniki 57001, Greece;1. Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany;2. Jülich-Aachen Research Alliance (JARA-HPC), RWTH Aachen University, D-52074 Aachen, Germany |
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| Abstract: | To elucidate a factor required for tumor-imaging 99mTc-labeled radiopharmaceuticals, in vivo behaviors of 99mTc-l-cysteine (99mTc-Cys) and 99mTc-2-mercaptoethylamine (99mTc-ME) were compared with that of 99mTc-dl-homocysteine (99mTc-Hcy) which had been found to accumulate in several experimental tumors. When these three complexes were intravenously injected into mice bearing Ehrlich solid tumor, their tumor affinity was found to depend on their binding ability to serum albumin; 99mTc-Hcy, the albumin-binding ability of which was highest of the three, was the most tumor-tropic. When the albumin-bound complexes of these three were injected, their tumor distributions were enlarged. These results suggest the importance of serum albumin in serving as a carrier for the transport of 99mTc-Hcy-related compounds to tumor tissue. |
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