Improved methods for the preparation of N6-(2-carboxyethyl)-NAD and poly(ethylene glycol)-bound NAD(H) |
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| Institution: | 1. State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China;2. State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China;3. Polymer Synthesis Laboratory, KAUST Catalysis Center, Physical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955, Saudi Arabia |
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| Abstract: | N6-(2-carboxyethyl)-NAD was prepared by alkylation of NAD with 3-iodopropionic acid instead of propiolactone, which is not commercially available now because of its carcinogenicity. This new method had the advantage of forming fewer by-products during the reaction. New methods for purification of diaminopoly (ethylene glycol) and poly (ethylene glycol)-bound NAD(H) were also described. As a results, it was possible to prepare highly purified PEG-NADH and PEG-NAD. |
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