The hexachlorotechnetate reagent in the synthesis,characterization and biodistribution of two novel lipophilic complexes |
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| Institution: | 1. Department of Chemistry & Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India;2. E-YUVA Centre, Panjab University, South Campus, Chandigarh 160025, India;3. Department of Microbial Biotechnology, Panjab University, Chandigarh 160025, India;4. SAIF/CIL, Panjab University, Chandigarh 160014, India |
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| Abstract: | The hexachlorotechnetate reagent has been used to synthesize lipophilic complexes of technetium-99m with polydentate ligands, using ligand exchange reactions and acetonitrile as an aprotic solvent. The complexes isolated were partially characterized by chromatographic (paper and HPLC) and electrophoretic methods. Preliminary data on biodistribution studies, carried out in rabbits, are also presented. This work documents that the hexachlorotechnetate reagent is a suitable intermediate for the rapid synthesis of new lipophilic complexes of technetium-99m. |
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