The effect of mercury exposure on liver mrna translatability and metallothionein in rainbow trout |
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| Institution: | 1. Centre for Technology in Water and Wastewater, School of Civil and Environmental Engineering, University of Technology Sydney, Ultimo, NSW, 2007, Australia;2. School of Engineering and Technology, Central Queensland University, QLD, 4701, Australia;3. Science and Math Program, Asian University for Women, Chattogram, 4000, Bangladesh;4. Mechanical Engineering Department, Prince Mohammad Bin Fahd University, Al Khobar, 31952, Saudi Arabia;5. Centre for Green Technology, School of Civil and Environmental Engineering, University of Technology Sydney, Ultimo, NSW, 2007, Australia;6. Mechanical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia;1. Departamento de Psiquiatría, Hospital Clínico Universitario de Valencia, Valencia, España;2. Departamento de Atención Primaria de Gandía, CS Grau de Gandía, Gandía, Valencia, España;3. Departamento de Salud Mental, INCLIVA, Instituto de Investigación Sanitaria, Hospital Clínico Universitario de Valencia, Valencia, España;4. Departamento de Medicina Clínica, Facultad de Medicina, Universidad de Valencia, Valencia, España;1. United Nations University Institute for Water, Environment and Health, 204-175 Longwood Road South, Hamilton, L8P 0A1 Ontario, Canada;2. Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA 94720, USA;3. CSIRO Agriculture, Clunies Ross Street, GPO Box 1700, Canberra, ACT 2601, Australia;4. Department of Environmental Sciences, University of California, Riverside, CA 92521, USA;5. Emeritus Soil and Water Specialist POB 1344, Graeagle, CA 96103, USA;1. Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN;2. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN;3. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN;4. Department of Business Development, Mayo Clinic, Rochester, MN;5. Department of Internal Medicine, Mayo Clinic, Rochester, MN;6. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN;7. AliveCor, Inc, San Francisco, CA;8. ZS Pharma, Inc, San Mateo, CA;9. University of California, Irvine, School of Medicine, Irvine, CA;1. Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan;2. Department of Clinical Biomechanics, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan |
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| Abstract: | 1. Young rainbow trout (Salmo gairdneri now known as Oncorhynchus mykiss) were exposed either to 0.2 μg–5 μg Hg2+/1 for two weeks or to 5 μg–100 μg Hg/1 for 4 days.2. The mRNA translatability in vitro was uniformly elevated in liver of exposed fish. There was a 3-fold increase in the synthesis of 10–14 kD proteins but a lesser increase in total proteins, as analyzed by polyacrylamide gel electrophoresis.3. Metallothionein levels in liver, measured by differential pulse polarography, were increased 3-fold at the highest exposure but to a lesser degree with lower exposure. |
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