A novel process of cyclodextrin production by the use of specific adsorbents: Part I. Screening of specific adsorbents |
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| Institution: | Mercian Co., Central Research Laboratories, Fujisawa, Kanagawa 251, Japan;State Key Laboratory of Chem/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China;College of Materials Science and Engineering, Xi’an University of Architecture and Technology, Xi’an, 710055, China;Department of Chemistry, School of Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, PR China;Department of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Chemical Reaction Engineering, Yan''an University, Yanan, Shaanxi, 716000, China;Malek-Ashtar University of Technology, Tehran, Iran;State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Novel adsorbents that are composed of ligand, spacer and support were chemically synthesized and the two consecutive screenings of them made it possible to determine the adsorbents that were most recommendable for α- and β-cyclodextrin (CD) production. First, ligands of high adsorption selectivity for each CD were screened from among the candidates (carboxylic acids) that are tied in ionic bonds to two types of strongly basic anion exchange resins as support. Secondly, ligand derivatives (as ligand and spacer) were bound in covalent bonds onto chilosan beads as support and then, the most suitable spacer length for the CDs' adsorption selectivity and capacity were investigated. An optimal mol ratio of ligand to amino group of the beads was also examined. Stearic acid was the most effective ligand for α-CD, whereas cyclohexanepropanamide-n-caproic acid was the best for β-CD. Adsorption selectivity of adsorbents derived from carboxylic acids (stearic and/or palmitic) and chitosan beads was almost 100%, while their adsorption capacities were large enough to meet the demand for economic production and purification of CDs on an industrial scale. |
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