Cholinergic receptors and catecholamine secretion from adrenal chromaffin cells of the toad |
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| Institution: | 1. Department of Nursing and Nutrition, University College Copenhagen, Copenhagen, Denmark;2. REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, Department of Clinical Research, University of Southern Denmark, Nyborg, Denmark;3. Bond Institute of Health and Sport, Bond University, Gold Coast, Australia;4. Division of Cancer Services, Princess Alexandra Hospital, Metro South Health, Queensland Health, Australia;5. Centre for Functioning and Health Research, Metro South Health, Queensland Health, Australia;6. School of Health and Rehabilitation Sciences, The University of Queensland, Australia;1. Department of Optometry and Vision Science, Hadassah Academic College, Jerusalem, Israel;2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; Felsenstein Research Medical Center; Neuro-Ophthalmology Division, Department of Ophthalmology, Rabin Medical Center – Beilinson Hospital, Petah Tikva, Israel |
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| Abstract: | 1. The effects of cholinergic drugs on catecholamine (CA) secretion from adrenal chromaffin tissue of the toad were studied.2. CA secretion was induced by ACh or nicotine, but not by muscarine.3. Hexamethonium inhibited the CA release evoked by ACh or nicotine, while d-tubocurarine only affected the nicotinic response. Atropine did not prevent the secretory response.4. Muscarine abolished the secretion induced by the agonists, this effect being prevented by atropine or gallamine, but not by pirenzepine.5. In conclusion, CA secretion in the toad is stimulated by activation of nicotinic receptors. Inhibitory muscarinic receptors are present, most likely of type M2, which may play a regulatory function. |
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