A single column,rapid quality control procedure for 6-[18F]fluoro-l-dopa and 6-[18F]fluorodopamine PET imaging agents |
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| Affiliation: | 1. Department of Marketing, University of Sydney Business School, Abercrombie building, Sydney, NSW 2006, Australia;2. Department of Economics, University of Sydney, Merewether building, Sydney, NSW 2006, Australia;3. IZA, Bonn, Germany;4. Univ Lyon, CNRS, GATE (UMR5824), 93 Chemin des Mouilles, F-69130 Ecully, France;1. Department of Economics, University of Melbourne, VIC 3010, Australia;2. Department of Economics, Monash University, VIC 3800, Australia;3. School of Economics and Centre for Behavioural and Experimental Social Science, University of East Anglia, NR4 7TJ, UK |
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| Abstract: | 6-[18F]Fluoro-l-dopa and 6-[18F]fluorodopamine are promising PET imaging agents for visualizing cerebral dopaminergic centers and cardiac sympathetic innervation and function. Administration to humans requires a means to determine the purity before injection. We describe such a method using HPLC with u.v. and radioactivity detection and a single high-speed C-18 column with gradient elution. The procedure can resolve within 10 min these fluorinated catechols, their isomers, and dihydroxyphenylalanine. The chemical and radiochemical purity, and specific activity, can be determined before injection. |
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