Elimination of caffeine interference in high-performance liquid chromatographic determination of cotinine in human plasma |
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| Institution: | 1. Beijing Bioprocess Key Laboratory, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, PR China;2. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, PR China;3. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China;1. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, 80309, USA;2. Center for Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA;3. Department of Chemistry and Biochemistry, University of Colorado Boulder, Boulder, CO, 80309, USA;4. Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, 80309, USA;5. Department of Physical Medicine & Rehabilitation and Center for Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA;6. Veterans Health Administration, Rocky Mountain Mental Illness Research Education and Clinical Center, Denver Veterans Affairs Medical Center (VAMC), Denver, CO, 80220, USA;7. Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), Denver, CO, 80220, USA;1. Department of Pharmacy, Birla Institute of Technology and Science, Pilani, India;2. National Institute of Pharmaceutical Education and Research (NIPER-G), Ministry of Chemicals and Fertilizers, Goverment of India, Guwahati, India;3. Rungta College of Pharmaceutical Sciences and Research, Bhilai, India;1. Microbial Processes and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Trivandrum 695 019, Kerala, India;2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India;3. Rajiv Gandhi Center for Biotechnology, Jagathy, Thiruvananthapuram 695 014, Kerala, India;4. Centre for Climate and Environmental Protection, School of Water, Energy and Environment, Cranfield University, Cranfield MK43 0AL, UK;5. College of Natural Resources and Environment, Northwest A & F University, Yangling, Shaanxi 712 100, China;1. The Danish Hydrocarbon Research and Technology Centre, Technical University of Denmark, Kongens Lyngby 2800, Denmark;2. Department of Mechanical Engineering, Technical University of Denmark, Kongens Lyngby 2800, Denmark;3. Department of Chemistry, Technical University of Denmark, Kongens Lyngby 2800, Denmark;4. Computational Science and Engineering Laboratory, ETH, Zürich CH-8092, Switzerland |
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| Abstract: | A high-performance liquid chromatographic method with ultraviolet photometric detection for the determination of cotinine in human plasma was described. The use of a 30-cm reversed-phase column and of a mobile phase consisting of water—methanol—0.1 M sodium acetate—acetonitrile (72:21:5.6:1.4, v/v), pH 4.1, eliminated caffeine interference. A simplified solid-phase extraction procedure was also performed for plasma samples. |
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