Studies on 67Ga uptake by mouse granuloma tissues |
| |
| Institution: | 1. Henan Key Laboratory of Biomolecular Recognition and Sensing, College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000, Henan, PR China;2. College of Chemistry and Chemical Engineering, Central South University, Changsha 410006, Hunan, PR China;3. School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, Jiangsu, PR China;4. Key Laboratory of Theoretical Organic Chemistry and Function Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China |
| |
| Abstract: | In connection with the uptake of 67Ga into the inflammatory tissues, such as granuloma tissues produced with turpentine oil, the influence of Fe3+ on the uptake of 67Ga into mouse granuloma and normal tissues and on the uptake of 125I-labeled transferrin and 59Fe were investigated. Fe3+ decreased the uptake of 67Ga into the liver and spleen, but had no influence on the uptake of 67Ga into the granuloma tissues. The uptake patterns of 125I-labeled transferrin and 59Fe in the granuloma tissues were not consistent with that of 67Ga at all. These results show that the uptake of 67Ga into the granuloma tissues occurs in a free, transferrin-unbound form, but into the liver and spleen in a transferrin-bound form. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
