Immunoscintigraphy of colorectal carcinoma with an anti-CEA monoclonal antibody: a critical review |
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| Institution: | 1. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul;2. Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul;3. Department of Oncology-Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu;4. Department of Hematology-Oncology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Bundang;5. Department of Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun;6. Department of Hematology-Oncology, Center for Gastric Cancer, National Cancer Center, Goyang;7. Department of Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul;8. Department of Hematology-Oncology, Haeundai Paik Hospital, University of Inje College of Medicine, Busan;9. Department of Hematology-Oncology, Ajou University School of Medicine, Ajou University Hospital, Suwon;10. Department of Oncology, Seoul St. Mary''s Hospital, Catholic University of Korea, Seoul;11. Biometric Research Branch, National Cancer Center, Goyang;12. Clinical Trials Department, DAEHWA Pharmaceutical Company Co., Ltd, Seoul;13. Department of Oncology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea;1. Laboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium;2. University Hospital Antwerp, Department of Nuclear Medicine, Edegem, Belgium;3. Molecular Imaging Center Antwerp, University of Antwerp, Antwerp, Belgium |
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| Abstract: | An anti-CEA monoclonal antibody (FO23C5), belonging to the IgG1a class, was used to perform several preclinical and clinical studies on radioimmunoscintigraphy (RIS) in patients with colorectal carcinoma. Preliminary screening on different tissues showed high specificity of this antibody for gastric and colorectal carcinomas. A pilot study on 51 patients with 64 localizations of colorectal carcinoma was realized, followed by a multicenter validation study in which, among 509 patients bearing CEA secreting tumors, 254 patients had primary or relapsed colorectal tumors. High sensitivity and specificity values were obtained by these studies and many “unsuspected” localizations were recorded. In order to better define the clinical utility of this approach, a prospective trial was run on 59 patients previously submitted to surgery for colorectal carcinoma and with suspected local relapses. A comparative evaluation of RIS, CT scan, US and MRI was performed. RIS and MRI have the highest value of accuracy (86%) followed by CT scan (68%) and US (54%). No adverse reactions were noticed in any of the patients examined. |
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