A comparative PET study using different 11C-labelled amino acids in Walker 256 carcinosarcoma-bearing rats |
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| Institution: | 1. Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands;2. Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan;1. Institute of Arctic and Alpine Research, Colorado University, Boulder, CO, USA;2. Department of Sociology and Institute for Society and Genetics, University of California, Los Angeles, CA, USA |
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| Abstract: | In Walker 256 carcinosarcoma-bearing rats, the dynamic distribution of l-1-11C]tyrosine, l-methyl-11C]methionine, l-1-11C]methionine and d-1-11C]methionine has been measured by PET. An equivalent tumor-imaging potential was observed for each of the three l-amino acids. Thirty minutes after injection, the tumors accumulated 57% (P < 0.01) more 11C-activity from l-1-11C]methionine than from l-methyl-11C]methionine. At the same point of time, the livers showed a 33% (P < 0.001) higher 11C-uptake with l-methyl-11C]methionine than with l-1-11C]methionine. The dynamic tissue data are in agreement with the findings in experiments with 14C-analogs. |
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