Strategies for enhancement of radioimmunotherapy |
| |
| Affiliation: | 1. Departments of Internal Medicine, Radiology and Pathology, University of California Davis Medical Center, Sacramento, CA 95816 USA;2. Department of Chemistry, University of California at Davis, Davis, CA 95616, U.S.A.;1. Department of Dental Materials and Prosthodontics, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil;2. Department of Preventive and Restorative Dentistry, Discipline of Endodontics, Araçatuba School of Dentistry, São Paulo State University - UNESP, Araçatuba, SP, Brazil;2. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain;4. Biosfer Teslab, Reus, Spain;11. Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Universitat Rovira i Virgili, IISPV, Reus, Spain;8. UMMM, INRA-Theix, St. Genes Champanelle, France;1. Department of Anatomy and Embryology, College of Veterinary Medicine, Alexandria University, Egypt;2. Department of Veterinary Biomedical Sciences, University of Georgia, Athens, GA, United States;3. Department of Population Health, Poultry Diagnostic and Research Center, University of Georgia, Athens, GA, United States;4. Department of Poultry Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, United States |
| |
| Abstract: | Two new strategies for increasing tumor uptake have been investigated. First the effect of interleukin-2 (IL-2) on tumor uptake of 125I-Lym-l antibody in nude mice was investigated. Secondly, the use of 67Cu-labeled Lym-1 was evaluated in patients. In nude mice implanted with Raji human lymphoma, a greater than 2-fold enhancement of tumor uptake of 125I-Lym-1 was observed after administration of PEG-interleukin-2 (PEG-IL-2). The macrocycle 1,4,8,11-tetraazacylcotetradecane-N,N′,N′,N'''-tetraacetic acid (TETA), synthesized specifically for copper chelation, has been conjugated to Lym-1 for 67Cu labeling of the monoclonal antibody (MoAb). There was no evidence for bone or normal marrow uptake and the residence time in the tumor was prolonged. Surprisingly, a dose of 4.4 mCi that was intended for imaging induced substantial tumor regression in a patient. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
