Recent advances in detection and control of infectious hematopoietic necrosis virus in aquaculture |
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| Affiliation: | 1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, 730070, China;2. College of Science, Gansu Agricultural University, Lanzhou, 730070, China;1. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, People’s Republic of China;2. College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People’s Republic of China;1. Key Laboratory of Oceanic and Polar Fisheries, Ministry of Agriculture and Rural Affairs; East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 300 Jungong Road, Shanghai, 200090, China;2. College of Marine Science, Shanghai Ocean University, 999 Huan Road, Shanghai, 200090, China;1. French Agency for Food, Environmental and Occupational Health and Safety, Ploufragan-Plouzané-Niort Laboratory, Fish Virology, Immunology and Ecotoxicology Unit, 29280, Plouzané, France;2. UBO University of Western Brittany, Brest, France |
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| Abstract: | Infectious hematopoietic necrosis (IHN) is one of the most important viral diseases of salmon and trout reared in culture. The disease remains untreatable with avoidance being the only control measure. Much has been learned about the chemical, physical, and serological characteristics of the rhabdovirus causing IHN, but critical gaps exist in our understanding of the biology of the virus in nature. The tools of molecular biology have provided improved methods for detection of pathogens and new strategies for control of viral diseases. This paper reviews several recent improvements in methods for detecting infectious hematopoietic necrosis virus including the application of enzyme-linked immunosorbent assays, development of monoclonal antibodies and DNA probes, and use of the polymerase chain reaction. New strategies for control of IHN through the use of better water treatment, more resistant fish, antiviral drugs or chemicals, and new generation vaccines are discussed. |
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