Effects of plumbagin on development of the parasitic nematodes Haemonchus contortus and Ascaris suum |
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| Institution: | 1. School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia;2. Graham Centre for Agricultural Innovations, Wagga Wagga, NSW, Australia;1. Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA;2. School of Mechanical, Industrial, and Manufacturing Engineering Oregon State University, Corvallis, OR 97331, USA;1. Marine Biology Research Group, Department of Biology, Ghent University, Ghent, Belgium;2. Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, Ghent, Belgium;3. Centrum for Molecular Phylogeny and Evolution, Ghent University, Ghent, Belgium;4. OD Taxonomy and Phylogeny, Royal Belgian Institute of Natural Sciences, Brussels, Belgium |
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| Abstract: | 1. Plumbagin (5-hydroxy,2-methyl-l,4-napthoquinone) inhibited the motility and survival of Haemonchus contonus first-stage larvae (L1) with an ed50 of 1 μg/ml, but was less effective in preventing the development of H. contortus to infective third-stage larvae in a faecal slurry assay.2. Of the structural analogs tested, plumbagin was the most potent in preventing development of L1 followed in decreasing order of potency by 1,4-napthoquinone, 5-hydroxy-1,4-napthoquinone (juglone) and 1,2-napthoquinone.3. Plumbagin had a biphasic effect on development of the fourth-stage Ascaris suum larvae that caused an increase in growth at low concentrations but was lethal at higher doses.4. Plumbagin and 1,2-napthoquinone partially inhibited embryonation of A. suum eggs. |
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