Comparative study on gastric absorption of albendazole and mebendazole in rats |
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| Institution: | 1. Maharaja Surajmal Institute of Pharmacy, Guru Gobind Singh Indraprastha University, New Delhi, India;2. Central Drugs Standard Control Organisation, New Delhi, India;3. NDMC Medical College, Hindu Rao Hospital, Delhi, India;1. Analytical Sciences, MRL, Merck & Co., Inc., Rahway, New Jersey 07065;2. Biopharmaceutics & Specialty Dosage Form, MRL, Merck & Co., Inc., West Point, Pennsylvania 19486;1. Department of Pharmacology and Toxicology, Catholic University of Córdoba, Córdoba, Argentina;2. Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA |
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| Abstract: | 1. A study was carried out to determine the kinetics of the gastric absorption of two wide spectrum benzimidazole anthelmintics, albendazole and mebendazole.2. The method used was gastric recirculation of solutions containing the drugs in concentrations ranging from 0.5 to 100 mM.3. The results obtained showed that absorption corresponds to first order kinetics, with diffusion constants of 0.0087 min−1 for albendazole and 0.0077 min−1 for mebendazole.4. Blood levels of the drugs for the whole range of concentrations were always higher in the case of albendazole. |
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