Minireview: Insights into anti-interferon-γ
autoantibodies |
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Authors: | Kriangkrai Chawansuntati Kritsadee Rattanathammethee Jiraprapa Wipasa |
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Institution: | Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand |
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Abstract: | The association between the presence of anti-interferon-γ autoantibodies and the onset of immunodeficiency with intracellular infections has been clearly established. No standard regimen to control the production of these pathogenic autoantibodies, apart from antimicrobial therapy to eliminate infections, contributes to the medical burden of this syndrome, which sometimes has a fatal outcome. In this review, we summarize the findings on anti-interferon-γ autoantibodies to facilitate further research and to provide guidance for treatment strategies. |
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Keywords: | Immune deficiency anti-interferon-γ antibodies intracellular organism infection adult-onset immunodeficiency |
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