Antiviral activity of human immunodeficiency virus type 1 Gag-specific cytotoxic T lymphocyte targeting is not necessarily intrinsically superior to envelope targeting |
| |
Authors: | Chen Diana Y Balamurugan Arumugam Ng Hwee L Yang Otto O |
| |
Institution: | Department of Microbiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. |
| |
Abstract: | Across several cohorts, human immunodeficiency virus type 1 (HIV-1) Gag- and Env-specific CD8(+) T lymphocyte (CTL) responses have demonstrated inverse and positive correlations, respectively, to viremia. The mechanism has been proposed to be superior antiviral activity of Gag-specific CTLs in general. Addressing this hypothesis, we created two HIV-1 constructs with an epitope translocated from Gag (SLYNTVATL, SL9) to Env, thereby switching the protein source of the epitope. A virus expressing SL9 in Env was similar to the original virus in susceptibility to SL9-specific CTLS. This finding suggests that Env targeting is not intrinsically inferior to Gag targeting for CTL antiviral activity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|