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| 日本榧树果实的化学成分研究 | |
| 引用本文： | 曹聪梅,董玫,王伟,杨雁,吴明,顾玉诚,史清文.日本榧树果实的化学成分研究[J].天然产物研究与开发,2009,21(5):737-739,775. |
| 作者姓名： | 曹聪梅 董玫 王伟 杨雁 吴明 顾玉诚 史清文 |
| 作者单位： | 1. 河北医科大学药学院天然药物化学教研室,石家庄,050017 2. 河北医科大学基础医学院,石家庄,050017 3. 河北医科大学药学院天然药物化学教研室,石家庄,050017;先正达集团Jealott's Hill研究中心,英国RG42 |
| 基金项目： | 河北省归国留学人员科技活动项目，河北省自然科学基金 |
| 摘 要： | 本文研究了日本榧树果实的化学成分。原植物用甲醇提取后经硅胶柱色谱、制备薄层色谱和制备HPLC色谱进行分离纯化，从日本榧树果实中分离得到了4个化合物，用质谱、红外、紫外、核磁等波谱方法鉴定为18-羟基弥罗松酚（1）、kayadiol（2）、花柏酚（3）和落叶松脂素（4），化合物1．3、4为首次从该植物果实中分离得到。用MTT法检测了化合物1～3的细胞毒性，在浓度100μmol／L时lisa细胞生存率分别为100．00％、26．30％和59．74％。 |
| 关 键 词： | 日本榧树 紫杉科 半日花烷 松香烷 木脂素 果实 细胞毒性 |
Chemical Constitutes in the Fruit of Torreya nucifera |
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| CAO Cong-me,DONG Mei,WANG Wei,YANG Yan,WU Ming,GU Yu-cheng,SHI Qing-wen.Chemical Constitutes in the Fruit of Torreya nucifera[J].Natural Product Research and Development,2009,21(5):737-739,775. | |
| Authors: | CAO Cong-me DONG Mei WANG Wei YANG Yan WU Ming GU Yu-cheng SHI Qing-wen |
| Abstract: | The chemical constituents of Torreya nucifera fruit were studied. The constituents were extracted with methanol and isolated by column chromatography on silica gel,and further purified by preparative TLC and HPLC. The compounds isolated were identified as 18-hydroxyferruginol (8,11,13-abietatriene-12,18-diol, 1) , kayadiol ( 8 ( 17), 13-labdiene-15,18-diol,2) ,hinokiol(8,11,13-abietatriene-3,12-diol,3) and pinoresinol(4) on the basis of spectral data. Compounds 1,3 and 4 were isolated from the fruits of Torreya nucifera for the first time. MTT method was used to evaluate the cytotoxicities of the three diterpenoids( 1-3). The survival rate of the Rsa tumor cells in the presence of compounds 1-3 at a concentration of 100 μmol/L were 100.00% ,26.30% and 59.74% ,respectively. |
| Keywords: | Torreya nucifera Taxaceae labdane abietane lignan fruit cytotoxicity |
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