B lymphocyte alloantigens controlled by theI region of the major histocompatibility complex in mice |
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Authors: | Günter J. Hämmerling Beverly D. Deak Gisela Mauve Ulrich Hämmerling Hugh O. McDevitt |
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Affiliation: | 1. Division of Immunology, Department of Medicine, Stanford University School of Medicine, 94305, Stanford, California, USA 2. Sloan-Kettering Institute for Cancer Research, 410 East 68th Street, 10021, New York, New York, USA
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Abstract: | An antiserum was produced by reciprocal immunization of congenic resistent inbred strains of mice which differed only with respect to theI andS regions of theH- 2 complex. This antiserum permitted the serological detection of lymphocyte alloantigens, designated Ia (=I region associated antigens). Ia determinants are only present on mature B lymphocytes. They could not be found on thymocytes, splenic or lymph node T cells, or on the majority of bone marrow cells. Absorption studies demonstrated existence of several Ia specificities which are associated with differentI region types. Thus, theI region of theH- 2 complex appears to control not only T-cellexpressed antigen specific immune response genes, but also B-cell-expressed Ia determinants. The relevance of the Ia alloantigen system for cellular interaction in immune reactions is discussed. |
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