Cross-reactivity between human and murine lymphocyte antigens: III. Reactivity of H-2 allo- and xenoantisera with human lymphoid cells |
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Authors: | Michele A Pellegrino Soldano Ferrone Kamal K Mittal Dietrich Götze Paul I Terasaki Ralph A Reisfeld |
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Institution: | 1. Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 2. University of Milan, Italy 3. Department of Surgery, University of California, Los Angeles, California 4. University of Munich, Deutschland
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Abstract: | H-2 alloantisera and antimouse lymphocyte xenoantisera react with 14%–100% of human lymphocytes from a panel of at least 80 unrelated people. Population and family studies did not reveal HL-A specificity of such lymphocytotoxic antibodies but indicated that the antibodies are directed against polymorphic antigenic determinants inherited in association with HL-A antigens. H-2 allo- and xenoantisera absorbed with human lymphoid cells and a panel of platelets bearing all the known HL-A specificities were still cytolytic when tested against murine lymphocytes, suggesting that only a small proportion of the heterogeneous population of H-2 antibodies react with human lymphocytes. On the other hand, HL-A alloantisera could be absorbed by lymphocytes from certain murine strains. These results suggest that the crossreactivity between human and murine lymphocytes is caused by antigens common to several HL-A (or H-2) types or by antigens linked to HL-A but not identical with them. |
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