Feline immunodeficiency virus cell entry |
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| Authors: | Frey S C Hoover E A Mullins J I |
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| Institution: | Department of Microbiology, University of Washington, Seattle, Washington 98195, USA. |
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| Abstract: | The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV. |
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