| Abstract: | Two separate control processes govern the cell cycle of rat C6 glioma cells. In subconfluent cultures growth inhibition is caused by cell contact interactions and the cell cycle is regulated primarily by changes in the duration of S phase. During advanced multilayering, medium depletion becomes the primary mechanism of growth inhibition and causes a pronounced G1 accumulation. Contact modulation acts by altering the velocity with which cells progress through the cell cycle, while depletion causes cycle arrest. |
