Intracellular enzymes and their localization in slender and stumpy forms of Trypanosoma brucei rhodesiense |
| |
Authors: | S Venkatesan RG Bird WE Ormerod |
| |
Institution: | London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, England |
| |
Abstract: | Acid phosphatase and cathepsin D activity is greater in stumpy than in slender forms, especially when estimations are made on a ‘light lysosomal’ fraction. Acid phosphatase is localized in the region of the flagellar pocket in slender forms but is present in lysosomes, phagolysosomes, autophagosomes and rough endoplasmic reticulum of stumpy forms. In stumpy forms dense bodies develop the macrocrystalline structure of peroxisomes. Intense enzyme activity in stumpy forms appears to be associated with absorption of lipid from the plasma by a mechanism similar to but of greater intensity than that described in atheromatous rabbit aorta. |
| |
Keywords: | lipids cholesterol ester lysosomes cathepsin acid phosphatase glucuronidase phagolysosome autophagosome peroxisome |
本文献已被 ScienceDirect 等数据库收录! |