Regulating intraflagellar transport |
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| Authors: | Lotte B Pedersen Søren T Christensen |
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| Institution: | Department of Biology, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. |
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| Abstract: | Kinesin-2 motors mediate anterograde intraflagellar transport (IFT) of IFT particles from the ciliary base to its tip, where particles are remodelled before retrograde transport by dynein 2 motors. Bardet-Biedl syndrome (BBS) and IFT-A proteins are now implicated in regulation of IFT assembly at the ciliary base and tip. |
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