The Uptake of a Labeled Double-Stranded Polynucleotide by Cultured Rabbit Kidney Cells: An Electron Microscopic Study |
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| Authors: | Philip H. Prose Alvin Friedman-Kien Jan Vil?ek |
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| Affiliation: | From the Departments of Pathology, Dermatology, and Virology, New York University School of Medicine, New York 10016 |
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| Abstract: | Polyribocytidylate-3H-polyriboinosinate (rC-3H:rI) enters cultured rabbit kidney cells from the surrounding medium within ½ hr after exposure. Grains are found in the cytoplasm, nucleus, and nucleolus. At 2 hr, grains are localized predominantly over the nucleolar regions. Subsequently, the grains in the nucleus become dispersed. A specific receptor site for the initiation of interferon production was not revealed. |
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