Suppression of experimental autoimmune thyroiditis in guinea pigs by pretreatment with thyroglobulin-coupled spleen cells |
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| Authors: | H Braley-Mullen J G Tompson G C Sharp M Kyriakos |
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| Affiliation: | 1. Departments of Medicine and Microbiology, University of Missouri, Columbia, Missouri 65212 USA;2. Department of Surgical Pathology, Washington University, School of Medicine, St. Louis, Missouri 63110 USA |
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| Abstract: | Pretreatment of Strain 2 and Strain 13 guinea pigs with guinea pig thyroglobulin (GPTG) coupled to syngeneic spleen cells (GPTG-SC) suppressed the development of experimental autoimmune thyroiditis (EAT) induced by immunization with GPTG in complete Freund's adjuvant (CFA). Antibody titers to GPTG were only minimally suppressed in GPTG-SC pretreated animals. GPTG-SC also suppressed the sensitization of periotneal exudate T lymphocytes which proliferate in vitro in the presence of GPTG. |
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