A robust high-sensitivity algorithm for automated detection of proteins in two-dimensional electrophoresis gels |
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| Authors: | Solomon, Jerry E. Harrington, Michael G. |
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| Affiliation: | Division of Biology and The Beckman Institute, California Institute of Technology Pasadena, CA 91125 USA |
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| Abstract: | The automated interpretation of two-dimensional gel electrophoresisimages used in protein separation and analysis presents a formidableproblem in the detection and characterization of ill-definedspatial objects. We describe in this paper a hierarchical algorithmthat provides a robust, high-sensitivity solution to this problem,which can be easily adapted to a variety of experimental situations.The software implementation of this algorithm functions as partof a complete package designed for general protein gel analysisapplications. |
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