Fused heterocyclic amido compounds as anti-hepatitis C virus agents |
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| Authors: | Aoyama Hiroshi Sugita Kazuyuki Nakamura Masahiko Aoyama Atsushi Salim Mohammed T A Okamoto Mika Baba Masanori Hashimoto Yuichi |
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| Affiliation: | Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan. aoyama@iam.u-tokyo.ac.jp |
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| Abstract: | We identified a fused heteroaromatic amido structure based on the phenanthridine skeleton as a superior scaffold for candidate drugs with potent anti-HCV activity. Among the compounds synthesized, a phenanthridine analogue with a 1,3-dioxolyl group (24) possessed the most potent anti-HCV activity (EC(50) value: 50 nM), with acceptable cytotoxicity. The structural development and structure-activity relationships of these compounds are described. |
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