Extreme variant of the short arm of chromosome 15 |
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| Authors: | U Friedrich A J Therkelsen A L Jørgensen M Caprani E Niebuhr |
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| Institution: | (1) Institute of Human Genetics, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark Tel. +45-8942-1684; fax +45-8612-3173; e-mail zitta@humgen-aau.dk, DK;(2) Cytogenetic Laboratory, Institute for Basic Research, Psychiatric Hospital in Aarhus, DK-8240 Risskov, Denmark, DK;(3) Department of Medical Genetics, The Panum Institute, University of Copenhagen, DK-2200 Copenhagen N, Denmark, DK |
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| Abstract: | Using fluorescence in situ hybridization, primed in situ labelling, and conventional cytogenetic staining we have characterized
an excessively enlarged short arm of chromosome 15. The likely mechanism explaining this variant chromosome involves amplification
of rDNA sequences followed by inverted insertional translocation between the enlarged sister chromatids of the short arm of
chromosome 15.
Received: 9 March 1995 / Revised: 16 October 1995 |
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