Comparative study on cytogenetic damage induced by homo-aza-steroidal esters in human lymphocytes |
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| Institution: | 1. Department of General Biology and Genetics, Faculty of Medicine, Aristotelian University, Thessaloniki 54006, Greece;2. Department of Chemotherapy, Theagenion Cancer Institute, Thessaloniki, Greece;3. Department of Pharmacology, Faculty of Medicine, Aristotelian University, Thessaloniki, Greece;4. Department of Pharmacy, Laboratory of Pharmaceutical Chemistry, University of Patras, Greece;1. College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China;2. Key Laboratory of Botanical Pesticide R & D in Shaanxi Province, Yangling 712100, Shaanxi, China;1. Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovi?a 3, 21000 Novi Sad, Serbia;2. Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovi?a 2, 21000 Novi Sad, Serbia;3. Department of Biology and Human Genetics, Faculty of Medicine, University of Ni?, 18108 Ni?, Serbia;4. Department for Cell and Tissue Engineering, Scientific Research Center for Biomedicine, Faculty of Medicine, University of Ni?, 18108 Ni?, Serbia;1. Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, ?lechtitel? 27, 78371, Olomouc, Czech Republic;2. Department of Organic Chemistry, University of Szeged, Dóm Tér 8, H-6720, Szeged, Hungary;3. Department of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Palacký University Olomouc and University Hospital Olomouc, Hněvotínská 3, 77515, Olomouc, Czech Republic;4. Department of Urology, Palacký University Olomouc and University Hospital Olomouc, I.P.Pavlova 6, 77900, Olomouc, Czech Republic |
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| Abstract: | The effect of PN,N-bis(2-chloroethyl)amino]phenylacetate esters of (compound 3) and 3β-hydroxy-17α-aza-d-homo-5α-androstane (compound 2) on sister-chromatid exchange (SCE) frequencies and on human lymphocytes proliferation kinetics was studied. The results are compared with those of the PN,N-bis(2-chloroethyl)phenylacetate esters of 3β-hydroxy-17α-aza-d-homo-5α-androstan-17-one (compound 1). All compounds were found to be active in inducing markedly increased SCE rates and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumour activity of these compounds was observed. |
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