Establishment of normal values for flash visual evoked potentials (VEPs) in preterm infants: a longitudinal study with special reference to two components of the N1 wave |
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| Institution: | 1. Department of Comparative Biosciences School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA;2. Comparative Biomedical Sciences Graduate Program, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA;3. Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin-Madison, 1010B McArdle Building, 1400 University Avenue, Madison, WI, 53706, USA;1. Division of Head and Neck Surgery & Communication Sciences, Department of Surgery, Duke University Medical Center, Durham, NC, USA;2. Computational Biology & Bioinformatics PhD Program, Duke University, Durham, NC, USA;3. Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC, USA;1. Department of Otorhinolaryngology – Head and Neck Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan;2. Department of Research and Technology Development, Rion Co., Ltd., Kokubunji, Tokyo 185-8533, Japan;1. Center for Adaptive Rationality, Max Planck Institute for Human Development, Berlin, Germany;2. Department of Psychology, TU Dresden, Dresden, Germany |
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| Abstract: | To establish normal values for flash visual evoked potentials WEN in the preterm period, we analyzed 356 records from 63 neurologically normal infants (26–35 weeks gestation) followed longitudinally. Using both sleep and drowsy state recording within the same session and a mean of 5.7 weekly recording sessions per infant, we hypothesized that the prominent negative wave (N1) consisted of 2 negative components, Nla (early) and N1b (late). This hypothesis could explain the previously reported variability in VEP indices.With a precise definition of the Nla peak, we were able to establish reference ranges for Nla peak latencies at various postmenstrual ages (PMA) which, unlike those previously reported, are narrow enough to be clinically useful. From a cross-sectional analysis we found that the Nla peak latency decreased with maturation at about 4.6 msec/week between 30 and 40 weeks PMA (P > 0.001).We also analyzed the N1 wave form and demonstrated its developmental maturation during this period. There were significant decreases in the amplitudes of both the Nla and N1b peaks with maturation (P > 0.001), but the decrease of the Nla amplitude was steeper than that of N1b The N1 wave form changed from a wave in which the early peak (Nla) was higher than the late peak (Nlb) into the reverse with N1b higher than Nla. This wave change may be related to developmental processes in the visual system. Longitudinal follow-up revealed that extra-uterine life may accelerate the maturation of the N1 wave form but has no effect on the decrease of the absolute values of peak latencies. |
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