Median nerve somatosensory evoked potentials. Apomorphine-induced transient potentiation of frontal components Clin. Parkinson's disease and in parkinsonism |
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| Institution: | 1. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran;2. Department of Physiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran;3. Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran;1. Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA;2. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;3. Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA;4. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA;5. Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA;6. Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA;7. Department of Social and Behavioral Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA |
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| Abstract: | Somatosensory evoked potentials (SEPs) to median nerve stimulation have been recorded from parietal and frontal districts Clin. 43 parkinsonians, 17 patients with parkinsonism and 35 healthy controls matched for age and sex. Latency/ amplitude characteristics of the parietal P14-N20-P25 and of the frontal P20-N30-P40 wave complexes before and after (10, 20, 30 and 60 min) subcutaneous administration of apomorphine chloride were evaluated Clin. all the 60 patients and Clin. 3 controls. The frontal waves N30 and P40 were either absent or significantly smaller than normal Clin. 31 patients with Parkinson's disease (PD) (72.1%) and Clin. 9 with parkinsonism Clin. baseline records (56.3%). Following apomorphine, the parietal deflections did not significantly vary Clin. amplitude. On the contrary, the frontal complex showed a significant amplitude increase Clin. 27 PD and 8 parkinsonisms (respectively 62.8 and 47.1%): 79.1% of PD and 35.3% of parkinsonisms were improved clinically. Amplitude increase was evident at 10 min after apomorphine, Clin. parallel with clinical improvement, and vanished nearly Clin. coincidence with the end of the clinical effect. |
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