Copper metabolism in analbuminaemic rats fed a high-copper diet |
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| Affiliation: | 1. Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.157, 3508 TD Utrecht, The Netherlands;2. Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2529 JB Delft, The Netherlands;1. Ufficio Studi, Associazione Nazionale della Pastorizia, 00187 Rome, Italy;2. Dipartimento di Scienze Agrarie, Università degli Studi di Sassari, 07100 Sassari, Italy;3. Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA;4. Dipartimento di Scienze Agrarie e alimentari, Università degli studi di Milano, 20133 Milan, Italy;5. Istituto di Biologia e Biotecnologia, Consiglio Nazionale delle Ricerche, 20133 Milan, Italy;1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;2. Gansu Key Laboratory of Animal Generational Physiology and Reproductive Regulation, Lanzhou 730070, China;1. Department of Animal Sciences, São Paulo State University “Júlio de Mesquita Filho” (UNESP), Jaboticabal 14884-900, SP, Brazil;2. Agência Paulista de Tecnologia dos Agronegócios (APTA), Colina 14770-000, SP, Brazil;3. Selko Feed Additives, 3811 Amersfoort, The Netherlands;4. Trouw Nutrition R&D, Campinas 13080-650, SP, Brazil |
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| Abstract: | Copper metabolism in male Nagase analbuminaemic (NA) rats was compared with that in male Sprague Dawley (SD) rats fed purified diets containing either 5 or 100 mg Cu/kg diet. Dietary copper loading increased hepatic and kidney copper concentrations in both strains to the same extent, but baseline values were higher in the NA rats. There was no strain difference in true and apparent copper absorption nor in faecal endogenous and urinary copper excretion. NA rats had higher levels of radioactivity in kidneys at 2 hr after intraperitoneal administration of 64Cu. As based on the distribution of added 64Cu, about 70% of plasma copper appeared to be in the non-protein compartment in the NA rats, whereas in SD rats, it was only about 1%. It is concluded that the NA rats are able to maintain a relatively normal metabolism of copper, even after dietary copper challenge. In the NA rats, zinc concentrations in kidneys, liver and urinary zinc excretion were elevated when compared with SD rats. The high-copper diet did not affect tissue zinc concentrations and apparent zinc absorption in both strains of rats. |
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