The origin of the human auditory brain-stem response wave II |
| |
| Institution: | 1. Beijing Key Laboratory of Gene Resource and Molecular Development, Beijing Normal University, China;2. Department of Otorhinolaryngology, General Hospital of the Second Artillery, PLA, Beijing, China;3. College of Life Sciences, Hainan Normal University, Haikou, China;1. Department of Family Medicine, Fars Petroleum Industry Health Organization, Shiraz, Iran;2. Department of Pharmacotherapy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran;1. Institute for Intelligent Systems, University of Memphis, Memphis, TN, USA;2. School of Communication Sciences & Disorders, University of Memphis, 807 Jefferson Avenue, Memphis, TN 38105, USA;3. Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, ON, Canada;4. Department of Psychology, University of Toronto, Toronto, ON, Canada;5. Institute of Medical Sciences, University of Toronto, ON, Canada;1. Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Universitätsstrasse. 2, 45117 Essen, Germany;2. Department of Game Management and Wildlife Biology, Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 21 Prague 6, Czech Republic;3. Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America;4. Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria;1. Psychology Department, University of California – Davis, Davis, CA, USA;2. California National Primate Research Center, University of California – Davis, Davis, CA, USA |
| |
| Abstract: | Auditory brain-stem responses (ABRs) were recorded from human subjects undergoing neurosurgical procedures which exposed the auditory nerve. Scalp recordings indicated that the latency of the negativity between waves (In) and II (In) and the latency of positive peak II (IIp) were shorter when the nerve was suspended in air than when the nerve was submerged in cerebrospinal fluid or saline, while earlier and later waves remained unaffected. These results could not be attributed to changes in stimulus or recording parameters or conduction velocity. Computational and somatosensory experimental evidence of stationary potentials generated by physical properties of the volume conductor, including changes in conductivity or geometry, are presented to develop a model of wave IIp generation. The results of this study suggest that wave IIp (and probably In) are manifestations of current flux asymmetries across conductivity boundaries created by the temporal bone-cerebrospinal fluid intradural space-brain-stem interfaces. The current flux asymmetries are generated as the propagating auditory nerve action potential crosses the conductivity boundaries. These results also indicate that the physical characteristics of the volume conductor and neural pathways must be considered when interpreting surface recorded evoked potentials. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
