Enhancement in dopamine uptake and release induced by monosodium l-glutamate from caudate nucleus under in vitro conditions |
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| Institution: | 1. Laboratorio de Neuroquímica, Facultad de Ciencias Biológicas, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico;2. Universidad de Investigación Médica en Patología Experimental, Hospital de Oncología del Centro Médico Nacional, Siglo XXI, I.M.S.S., México, D.F., Mexico;1. Institute of Sport Science, University of Physical Education, Alkotas u. 44, TF, Budapest, Hungary;2. Graduate School of Sport Sciences, Waseda University, Saitama, Japan;3. Institute of Physical Education and Sport Science, University of Szeged, Hungary;4. Department of Microbiology and Immunology, Sealy Center for Molecular Medicine, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA;1. Departamento de Patología Animal. Facultad de Veterinaria C/ Miguel Servet 177, 50013 Zaragoza, Spain;2. Gabinete Técnico Veterinario S.L. C/ Isla Conejera s/n, 50013 Zaragoza, Spain;3. Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece;1. Neuroscience Department, UConn School of Medicine, Farmington CT, United States;2. Neuroscience Program & Psychology Department, Trinity College, Hartford, CT, United States;3. Neuroscience Program & Department of Biology, University of Hartford, West Hartford, CT, United States;1. Department of Physiology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China;2. Department of Neurosurgery, Qilu Hospital of Shandong University and Brain Science Research Institute, Shandong University, 107#, Wenhua Xi Road, Jinan, Shandong 250012, PR China;3. Department of Medical Psychology Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China;1. Department of Orthopedics, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong, China;2. Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong, China;3. Department of Orthopedics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China |
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| Abstract: | l-Glutamate has an excitatory and cytotoxic effect on the central nervous system. It was shown previously that norepinephrine and dopamine uptake and release were affected by in vivo administration of glutamate to adult rats. The kinetic parameters, Km and Vmax of 14C]DA uptake and release were measured on synaptosomal and slices from caudate nucleus under in vitro conditions at different glutamate concentrations. Results showed an important increase in 14C]DA uptake on synaptosomal (> 100%) and slices by lower glutamate concentrations, the affinity for transport system was increased (100%) and its release of high potassium evoked was also increased at 0.5 μM of glutamate. The results suggest the possibility that glutamate may modify DA uptake and release interacting with the DA transporter complex at the synaptic level. |
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