Iron and copper metabolism in analbuminaemic rats fed a high-iron diet |
| |
| Affiliation: | 1. Nutraceuticals Research Group, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia;2. Metabolomics Platform, Rovira i Virgili University, IISPV, Avinguda Països Catalans 26, 43007 Tarragona, Spain;3. Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), C/ Monforte de Lemos 3-5, 28029, Madrid, Spain;4. Biosfer Teslab, Plaça Prim 10, 2on 5a, 43201 Reus, Spain;5. Centre for Asthma and Respiratory Disease, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia |
| |
| Abstract: | The metabolism of iron and copper in male Nagase analbuminaemic (NA) and Sprague Dawley (SD) rats was compared. Relative liver weight was higher and spleen weight significantly lower in NA than SD rats. In NA rats, red blood cell count, haemoglobin and haematocrit were lower, whereas plasma transferrin, total iron-binding capacity and mean corpuscular haemoglobin were higher when compared with SD rats. Iron concentrations in plasma, liver, kidneys and heart were higher, and those in the spleen and tibia were lower, in NA rats. The iron concentrations in liver and spleen were positively correlated with the amount of brown pigment as observed histopathologically. Bile flow as well as biliary iron and copper excretion were higher in NA than SD rats. Copper concentrations in liver, kidneys and plasma were higher in NA rats. Plasma levels of ceruloplasmin were about two-fold higher in NA rats. The feeding of a high-iron diet reduced kidney copper concentrations in both strains of rats, which was associated with a decrease in the absorption and biliary excretion of copper. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
