The mechanisms and molecules involved in cytoadherence and pathogenesis of Trichomonas vaginalis |
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| Affiliation: | 1. Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA;2. Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA;3. College of Agriculture, Auburn University, Auburn, Alabama, USA;1. INCITAP, CONICET, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de La Pampa, Santa Rosa, La Pampa, Argentina;2. Instituto Nacional de Tecnología Agropecuaria (INTA), Anguil, La Pampa, Argentina;3. CONICET, Universidad Nacional del Litoral, Paraje el Pozo, Santa Fe, Argentina;1. Unidad PET/TC, CETIR, España;2. Servicio de Radiología, Centro Médico Teknon, Barcelona, España;1. Laboratory of Innovations in Therapies, Education and Bioproducts, Oswaldo Cruz Institute/FIOCRUZ, Av. Brasil 4365, 21045-900, Manguinhos, Rio de Janeiro, Brazil;2. Laboratory of Cell Biology, Oswaldo Cruz Institute/FIOCRUZ, Av. Brasil 4365, 21045-900, Manguinhos, Rio de Janeiro, Brazil;3. Applied Mathematics, Rio de Janeiro State University, Rua São Francisco Xavier, 524, 20559-900, Brazil;1. Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Avenida Instituto Politécnico Nacional # 2508, Col. San Pedro Zacatenco, México DF C.P. 07360, Mexico;2. Departamento de Bioquímica, Facultad de Medicina de la UNAM, México D.F., Mexico;1. Department of Parasitology, Research Institute of Ophthalmology, El-Giza, Egypt;2. Department of Parasitology, Faculty of Medicine, Fayoum University, Egypt;3. Department of Parasitology, Faculty of Medicine, Cairo University, Egypt;4. Department of Parasitology, Faculty of Medicine, October 6 University, Egypt;5. Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, Egypt |
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| Abstract: | All urogenital mucosal pathogens must overcome host factors and responses in order to colonize the mucosa and establish infection. These include the extensive mucus layer, nutrient-limiting conditions antibody responses and the constant fluid flow of the vagina. In this article, John Alderete, Michael Lehker and Rossana Arroyo review the recent work describing the specificity by which the protozoan. Trichomonas vaginalis, adheres to the vaginal epithelial cells via four surface proteins. They discuss three distinct signals that may be received by the parasite upon recognition and binding to these cells, illustrating the type of adaptive responses evolved in the establishment and maintenance of infection. |
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