Novel solid-phase extraction strategy for the isolation of basic drugs from whole blood Preliminary study using commercially available extraction cartridges |
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| Affiliation: | 1. Northern Ireland Forensic Science Laboratory, 151 Belfast Rd, Carrickfergus BT38 8PL, UK;2. Home Office Forensic Science Service, Aldermaston, Reading RG7 4PN, UK;1. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea;2. Department of Anesthesiology and Pain Medicine, Seoul National University College of Medicine, Seoul, South Korea;1. School of Physics and Materials Engineering, Dalian Minzu University, Dalian, 116600, PR China;2. Institute of Electrostatics and Special Power, Dalian University of Technology, Dalian, 116024, PR China;1. Surface Coating and Corrosion Department, Institute for Color Science and Technology, Tehran, Iran;2. Chemical and Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran;3. Department of Chemical Engineering, Faculty of Engineering, Golestan University, Aliabad Katool, Iran;1. Department of Haematology and Medicine, Launceston General Hospital, Launceston, TAS, Australia;2. Department of Surgery, Launceston General Hospital, Launceston, TAS, Australia;3. Menzies Institute for Medical Research, University of Tasmania, TAS, Australia;4. Faculty of Health Sciences, University of Tasmania, TAS, Australia;5. Calvary Health Care, Launceston, TAS, Australia |
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| Abstract: | A novel strategy for the solid-phase extraction of basic drugs has been developed using commercial extraction cartridges. The procedure involves the sequential application of very different isolation mechanisms, viz. hydrophobic extraction on non-porous carbon followed by ionic extraction on a strong cation exchanger. This approach to extraction achieves both high recoveries and clean extracts when analysed by GC-MS. The potential for automation has been demonstrated using commercial sample preparation equipment. |
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