Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo |
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| Authors: | Zarei Shohreh Abraham Shahnaz Arrighi Jean-Francois Haller Olivier Calzascia Thomas Walker Paul R Kündig Thomas M Hauser Conrad Piguet Vincent |
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| Affiliation: | Department of Immunology and Allergy, University Hospital of Geneva, Geneva, Switzerland. |
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| Abstract: | Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections. |
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