The dinB operon and spontaneous mutation in Escherichia coli |
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| Authors: | McKenzie Gregory J Magner Daniel B Lee Peter L Rosenberg Susan M |
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| Affiliation: | Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030-3411, USA. |
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| Abstract: | Apparently conflicting data regarding the role of SOS-inducible, error-prone DNA polymerase IV (DinB) in spontaneous mutation are resolved by the finding that mutation is reduced by a polar allele with which dinB and neighboring yafN are deleted but not by two nonpolar dinB alleles. We demonstrate the existence of a dinB operon that contains four genes, dinB-yafN-yafO-yafP. The results imply a role for yafN, yafO, and/or yafP in spontaneous mutation. |
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