Kinetics of histologic changes in human melanoma after local immunotherapy with BCG |
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| Authors: | A Khalil H Rappaport J L Misset |
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| Institution: | (1) Institut de Cancérologie et d'Immunoténétique (INSERM), Hôpital Paul Brousse, 14-16 avenue Paul Vaillant Couturier, F-94800 Villejuif, France;(2) Departments of Pathology, University of Cairo, Faculty of Medicine, Cairo, Egypt;(3) Present address: Department of Anatomic Pathology, City of Hope, National Medical Center, 91010 Duarte, Cal., U.S.A. |
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| Abstract: | Summary BCG was injected directly into multiple metastatic cutaneous melanomas. Individual metastases were excised sequentially at planned intervals. We found that a progressive necrosis of tumor cells was followed first by a severe exudative reaction and subsequently by the formation of BCG granulomas which completely replaced the tumor mass. No changes were observed in noninjected subcutaneous nodules excised simultaneously with injected nodules at 36 hrs.Supported in part by USPHS Grant Number 7 R10 CA18044-01 and Hematopathology Tutorials, Inc. |
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