Effect of pentoxifylline,a multidrug resistance reversal agent,on haemopoietic stem cell homing. |
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| Authors: | R. P. Gude M. P. Chitnis S. G. A. Rao |
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| Affiliation: | 1. Department of Mathematics, The University of Hong Kong, Hong Kong;2. School of Mathematics and Statistics and Hubei Key Laboratory of Mathematical Sciences, Central China Normal University, Wuhan 430079, China;3. School of Mathematical Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China |
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| Abstract: | This paper investigates the mechanism of mouse haemopoietic stem cell homing into the cytoskeleton depolymerising agent Pentoxifylline was used, and shown to inhibit stem cell homing. The inhibition was reversible after 6 hours. The results obtained suggest that the haemopoietic stem cell homing receptor is anchored to cytoskeletal support intracellularly. |
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