| 黔产钩藤茎、叶化学成分及抗肿瘤活性研究 |
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| 引用本文： | 刘 扬,张 妮,罗 俊,王苗苗,潘卫东. 黔产钩藤茎、叶化学成分及抗肿瘤活性研究[J]. 广西植物, 2021, 41(7): 1061-1069 |
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| 作者姓名： | 刘 扬 张 妮 罗 俊 王苗苗 潘卫东 |
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| 作者单位： | 贵州医科大学,省部共建药用植物功效与利用国家重点实验室,贵阳 550014;贵州省中国科学院天然产物化学重点实验室/贵州省天然药物工程研究中心,贵阳 550014;贵州省中国科学院天然产物化学重点实验室/贵州省天然药物工程研究中心,贵阳 550014;贵州中医药大学,贵阳 550025 |
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| 基金项目： | 国家自然科学基金(81660580); 贵州省科技支撑项目(黔科合支撑 [2019]2757号); 贵州省中药材现代农业产业技术体系建设项目(GZCYTX2015-0202)[Supported by the National Natural Science Foundation of China(81660580); Science and Technology Department of Guizhou Province, China(QKHZC [2019]2757; Construction Project of Modern Agricultural Industry Technology System of Traditional Chinese Medicinal Materials in Guizhou Province(GZCYTX2015-0202)]。 |
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| 摘 要： | 钩藤富含生物碱类成分且资源丰富,具有清热平肝、息风定惊等作用.为明确钩藤茎、叶的物质基础,该文采用硅胶柱色谱、Sephadex LH-20及半制备HPLC等色谱技术对其进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构,并采用MTT法对人白血病细胞株K562、HEL进行体外抗肿瘤活性筛选.从钩藤茎中分离得到7个化合物...
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| 关 键 词： | 钩藤 化学成分 分离纯化 结构鉴定 抗肿瘤活性 |
| 收稿时间： | 2020-04-06 |
Chemical constituents of stems and leaves from Uncaria rhynchophylla in Guizhou and their antitumor activities |
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| LIU Yang,ZHANG Ni,LUO Jun,WANG Miaomiao,PAN Weidong. Chemical constituents of stems and leaves from Uncaria rhynchophylla in Guizhou and their antitumor activities[J]. Guihaia, 2021, 41(7): 1061-1069 |
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| Authors: | LIU Yang ZHANG Ni LUO Jun WANG Miaomiao PAN Weidong |
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| Affiliation: | 1. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; 2. Key Laboratory of Chemistry for Natural Product of Guizhou Province and Chinese Academy of Sciences/Guizhou Provincial Engineering Research Center for Natural Drugs, Guiyang 550014, China; 3. Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China |
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| Abstract: | |
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| Keywords: | Uncaria rhynchophylla chemical constituents isolation and purification structure identification antitumor activity |
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