Protective effects of nocardia delipidated cell mitogen on the mucosa of the small intestine after irradiation of germ-free piglets. |
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| Authors: | Hana Kozakova Leos Mandel Ilja Trebichavsky Jirina Kolinska Rita Barot-Ciorbaru |
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| Affiliation: | 1. Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India;2. Department of Endocrinology, Institute of Post Graduate Medical Education and Research, Kolkata, 700007, India;1. Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA 16802, USA;2. Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA;1. Technische Universität München, TUM School of Education, Arcisstr. 21, 80333 München, Germany;2. Syracuse University, School of Education, 161 Huntington Hall, Syracuse, NY 13244, USA;1. Military Institute of Engineering, Chemical Engineering Department, Praça Gal. Tiburcio 80, Rio de Janeiro, 22290-270, Brazil;2. National Institute of Technology, Catalysis Division, Av. Venezuela 82, Rio de Janeiro, 20081-312, Brazil;3. Fluminense Federal University, Chemical Engineering Department, Rua Passo da Pátria, 156, Niterói, 24210-240, Brazil;1. Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China;2. Marine Environmental and Engineering Geological Survey, Guangzhou Marine Geological Survey, Guangzhou 510075, China |
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| Abstract: | The radioprotective effect of the bacterial immunomodulator Nocardia delipidated cell mitogen (NDCM) on intestinal mucosa and disaccharidase activities was studied in irradiated germ-free piglets. Three-week-old germ-free (GF) piglets were intragastrically pretreated with 1 mg NDCM per 1 kg body weight. The piglets were whole-body irradiated with 2.5 Gray five days after the NDCM pretreatment and sacrificed eight days after irradiation. In the non-irradiated group of GF piglets, NDCM application stimulated lactase activity and markedly increased sucrase activity. This stimulatory effect of NDCM disappeared after irradiation and the piglets exhibited a normal activity of lactase in the jejunal brush-border membrane vesicles, while the sucrase activity decreased to the level found in irradiated controls. NDCM-pretreated intestinal mucosa contained some infrequent lymphocytes which disappeared from the control irradiated tissue. It also exhibited less injury of the epithelium and stroma cells. |
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