Pin-pointing a new DAP kinase function: the peptidyl-proly isomerase Pin1 Is Negatively Regulated by DAP kinase-mediated phosphorylation |
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| Authors: | Bialik Shani Kimchi Adi |
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| Institution: | Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. |
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| Abstract: | In this issue of Molecular Cell, Lee et al. (2011) identify the peptidyl-prolyl isomerase Pin1 as a substrate of DAP kinase, simultaneously providing a critical regulatory mechanism for Pin1 inhibition and a potential mechanism that accounts for DAPK's tumor-suppressive activities. |
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