槐杞黄颗粒治疗原发免疫性血小板减少症患儿疗效及对血小板参数、外周血Treg/Th17和CD4/CD8的影响

摘要 目的：探讨槐杞黄颗粒治疗原发免疫性血小板减少症（ITP）患儿疗效及对血小板参数、外周血Treg/Th17和CD4/CD8的影响。方法：2019年8月到2021年5月选择在本院诊治的免疫性血小板减少症患儿60例作为研究对象，根据1:1简单分配原则把患儿分为槐杞黄颗粒组与对照组各30例。对照组给予常规药物-注射用人免疫球蛋白治疗，槐杞黄颗粒组以对照组为基础，给予槐杞黄颗粒治疗，两组都治疗观察3个月，观察患儿治疗疗效与血小板参数、外周血Treg/Th17和CD4/CD8的变化情况。结果：治疗后槐杞黄颗粒组的总有效率为96.7 %，明显高于对照组的80.0 %（P<0.05）。槐杞黄颗粒组的起效时间少于对照组，疗效维持时间多于对照组，两两对比有明显差异（P<0.05）。两组治疗后的血小板计数、血小板参数都明显高于治疗前，槐杞黄颗粒组也明显高于对照组（P<0.05）。两组治疗后的外周血Treg/Th17和CD4/CD8比值都明显高于治疗前，槐杞黄颗粒组明显高于对照组（P<0.05）。结论：槐杞黄颗粒治疗原发免疫性血小板减少症患儿能有效提高治疗效果，可缩短起效时间，延长疗效持续时间，还能有效改善患儿的血小板计数、血小板参数，提高外周血Treg/Th17和CD4/CD8水平。

Curative Effect of Huaiqihuang Granule in The Treatment of Children with Primary Immune Thrombocytopenia and Its Effect on Platelet Parameters, Peripheral Blood Treg/Th17 and CD4/CD8

ABSTRACT Objective: To investigate the efficacy of Huaiqihuang granule in the treatment of children with idiopathic thrombocytopenic purpura (ITP) and its effect on platelet parameters, peripheral blood Treg/Th17 and CD4/CD8. Methods: From August 2019 to May 2021, 60 children with immune thrombocytopenia treated in our hospital were selected as research subjects. Children were divided into Huaiqi Huang granule group according to the 1:1 simple distribution principle and the matched group. The matched group was given conventional drug-injection human immunoglobulin treatment, and the group was treated on the basis of the matched group. Both groups were treated for 3 months to observe the efficacy of treatment, platelet parameters, peripheral blood Treg / Th17 and CD4 / CD8. Results: Post-treatment, the total effective rates of Huaiqihuang granule group were 96.7 %, which were higher than 80.0 % of matched group(P<0.05). The onset time of Huaiqihuang granule group were shorter than that of the matched group, and the duration of the curative effect were longer than that of the matched group. there were difference compared between the two groups(P<0.05). The platelet count and platelet parameters in the two groups Post-treatment were higher than those pretherapy, and the Huaiqihuang granule group were also higher than that in the matched group(P<0.05). The Peripheral blood Treg/Th17 and CD4/CD8 in both groups post-treatment were higher than that pretherapy, and the Huaiqihuang granule group were higher than that in the matched group (P<0.05). Conclusion: Huaiqihuang granules in the treatment of children with primary immune thrombocytopenia can effectively improve the therapeutic effect, shorten the onset time and prolong the duration of the effect, and can also effectively improve the platelet count and platelet parameters in children, increase Peripheral blood Treg/Th17 and CD4/CD8.