Antifungal amides from Piper arboreum and Piper tuberculatum |
| |
Authors: | Vasques da Silva Renata Navickiene Hosana M Debonsi Kato Massuo J Bolzani Vanderlan da S Méda Christiane I Young Maria Claudia M Furlan Maysa |
| |
Institution: | Instituto de Química, Universidade Estadual Paulista, CP 355, 14800-900, Araraquara-SP, Brazil. maysaf@iq.unesp.br |
| |
Abstract: | In continuation of our study of the Piperaceae we have isolated several amides, mainly those bearing isobutyl, pyrrolidine, dihydropyridone and piperidine moieties. Bioactivity-guided fractionation of extracts from leaves of Piper arboreum yielded two new amides, N-10-(13,14-methylenedioxyphenyl)-7(E),9(Z)-pentadienoyl]-pyrrolidine (1), arboreumine (2) together with the known compounds N-10-(13,14-methylenedioxyphenyl)-7(E)-pentaenoyl]-pyrrolidine (3) and N-10-(13,14-methylenedioxyphenyl)-7(E),9(E)-pentadienoyl]-pyrrolidine (4). Catalytic hydrogenation of 3 yielded the amide N-10-(13,14-methylenedioxyphenyl)-pentanoyl]-pyrrolidine (5). We also have isolated six amides (6-11) and two antifungal cinnamoyl derivatives (12, 13) from seeds and leaves of Piper tuberculatum. Compounds 1-11 showed antifungal activity as determined by direct bioautography against Cladosporium sphaerospermum while compounds 3-4 and 6-13 also showed antifungal activity against C. cladosporioides. |
| |
Keywords: | Piper arboreum Piper tuberculatum Piperaceae Amides Antifungal activity |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|